A rare case of Crohn's ileitis in a patient with constitutional mismatch repair deficiency

 
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2017 (EN)
A rare case of Crohn's ileitis in a patient with constitutional mismatch repair deficiency (EN)

Kaimakliotis, Pavlos
Giardiello, Francis
Eze, Ogechukwu
Truta, Brindusa

Constitutional mismatch repair deficiency (CMMRD), a variant of Lynch syndrome, is a rare disease characterized by café-au-lait spots, oligopolyposis, glioblastoma and lymphoma. A 24-yearold male, under surveillance for CMMRD, developed Crohn's ileitis after total colectomy with end ileostomy for colorectal cancer and failed to respond to oral corticosteroids. The patient underwent induction and maintenance of remission with vedolizumab infusions. We report the first patient with CMMRD developing Crohn's disease. The choice of immunosuppressive therapy in these patients is challenging and needs to be made according to their risk for malignancy.Keywords Crohn's disease, familial cancer, vedolizumab, constitutional mismatch repair deficiencyAnn Gastroenterol 2017; 30 (3): 370-372 (EN)

info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Society of Gastroenterology (EN)

2017-04-27


Hellenic Society of Gastroenterology (EN)

1792-7463
1108-7471
Annals of Gastroenterology; Volume 30, No 3 (2017); 370 (EN)



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