Treatment of H. pylori infection: Current recommendations

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2007 (EN)
Treatment of H. pylori infection: Current recommendations (EN)

Rokkas, T.

Helicobacter pylori (H. pylori) was isolated twenty years ago, and since then a significant volume of literature concerning it's significance for gastric and extragastric pathology has been produced. The relevance of H. pylori infection and the value of its eradication in disease areas and the resultant statements with the corresponding level of recommendation, have been discussed in various consensus meetings. The recommendation to eradicate H. pylori in patients with peptic ulcer disease includes active and inactive disease, complicated disease and following gastric surgery for peptic ulcer. H. pylori eradication is also strongly recommended in H. pylori-positive patients with low-grade mucosa associated lymphoid tissue lymphoma, although subsequent lifelong surveillance is needed. Individual patients with H. pylori-positive high-grade mucosa associated lymphoid tissue lymphoma should undergo H. pylori eradication as first-line treatment. Atrophic changes in the gastric mucosa are associated with an increased risk for possible progression to gastric cancer and therefore this condition requires intervention by the eradication of H. pylori, although there is no proof that progression to neoplasia occurs. In addition, H. pylori eradication is now strongly recommended in infected patients who are first-degree relatives of gastric cancer patients, and in H. pylori positive patients who wish to receive eradication therapy following full consultation with their physician. The recommendation to eradicate H. pylori in patients with functional dyspepsia is made with the understanding that the likelihood of a symptomatic benefit is likely to be modest, with the recent meta-analysis indicating that 15 infected patients need to be treated to cure one case of non-ulcer dyspepsia. Key words: H. pylori, management. (EN)




Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 18, No 2 (2005) (EN)

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