Gastric neuroendocrine tumors: Biology and management

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Annals of Gastroenterology
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2007 (EN)
Gastric neuroendocrine tumors: Biology and management (EN)

Christopoulos, E. Papavassiliou2, C.

Neoplasms may originate from any of the endocrine cells of the gastric wall, most commonly the enterochromaffinlike (ECL) cells of the oxyntic mucosa. In recent years, the increasing number of screening gastroscopies and biopsies, and the widespread application of sophisticated immunohistochemical stains for neuroendocrine markers, have resulted in the frequent detection of ECL tumors. The latter are regarded as a separate clinicopathological entity seen in the setting of hypergastrinemic states, and their pathogenesis follows the sequence “hyperplasia – dysplasia – neoplasia”. According to the most recent WHO classification, gastric neuroendocrine tumors (NETs) are generally divided into “well-differentiated NETs” (class 1a), “welldifferentiated neuroendocrine carcinomas (NECs)” (class 1b) and “poorly differentiated NECs” (class 2). Well-differentiated tumors (NETs and NECs), for which the historic term “carcinoid” is still in use, include three subgroups: Type I (70-80%), associated with chronic atrophic gastritis, which are benign (class 1a) ECL cell tumors in the vast majority of cases; Type II ( (EN)




Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 18, No 2 (2005) (EN)

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