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Annals of Gastroenterology
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2007 (EN)
Role of Photodynamic Therapy in Gastroenterology (EN)

Karamanolis, E.G. Mallas, G.

Photodynamic therapy (PDT) is a cancer treatment modality that combines the use of a photosensitizing agent and a photosensitizer (a drug that selectively accumulates and is preferentially retained in dysplastic or neoplastic cells). When activated by light of a specific wavelength in the presence of oxygen, the photoactive compound produces rapid cell death in the target tissue. Following health agency approvals throughout the world for various cancers and other diseases, PDT is gradually being accepted as a standard modality to be added to the medical practitioner’s armamentarium. In Gastroenterology, PDT has been approved for the treatment of Barrett´s esophagus and of early esophageal cancer, and as palliative therapy for advanced esophageal carcinoma whereas, superficial gastric cancer, non-resectable cholangiocarcinoma, and pancreatic carcinoma have been investigated in PDT trials. This article represents an extensive survey of literature to review the experience gained with PDT and to assess its clinical value in the management of gastrointestinal diseases. (EN)




Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 18, No 2 (2005) (EN)

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