Lipapheresis in the management of hyperlipidemic pancreatitis: Our experience in a series of 7 patients

 
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Annals of Gastroenterology
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Lipapheresis in the management of hyperlipidemic pancreatitis: Our experience in a series of 7 patients (EN)

G. Poulakou,2 E.J. Giamarellos-Bourboulis,, G.C. Nikou,1 Ch. Toubanakis,
N. Katsilambros1, D. Stamatiadis,

Aim of the study : To evaluate the efficacy of lipapheresis in the management of hyperlipidemic pancreatitis (HLP). Methodology : Seven patients (pts), (6 males and 1 female) with mean age 40.8 years (range: 26 - 64 years) were included. The diagnosis of pancreatitis was based upon clinical symptoms, serum and urine amylase levels and/or abdominal Computed Tomography (C/T) findings. Diagnosis of HLP was confirmed, as all pts had serum triglyceride (TG) levels of more than 1000mg/dl. All pts underwent 1-3 sessions of plasma treatment, by using double cascade filtration. During each session of plasmapheresis, three liters of plasma were exchanged. All pts were followed-up monthly after their discharge, for 6 months. Results : In 3/7 (43%) a significant reduction of serum TG and pancreatic enzymes was noted, within a few hours from lipapheresis. In the remaining pts, the same results were noted after a second (2/7,28.5%) or third (2/7,28.5%) session of the procedure. Also, an impressive improvement of pts’ clinical signs was observed. All sessions were well tolerated. During the follow-up period, none of the pts reported any episodes of abdominal pain or vomiting, while their serum TG levels were well below 1000mg/dl. Moreover, serum and urine amylase were within normal limits over the same period. Conclusion : It seems that lipapheresis is a promising and safe treatment in pts with HLP. However, more studies with a larger patient group are needed for further evaluation of its efficacy. Key words : Pancreatitis, Hypertriglyceridemia, lipapheresis, plasma exchange (EN)

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Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Society of Gastroenterology (EN)

2007-03-19


Hellenic Society of Gastroenterology (EN)

1792-7463
1108-7471
Annals of Gastroenterology; Volume 18, No 3 (2005) (EN)



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