Is complete mesocolic excision oncologically superior to conventional surgery for colon cancer? A retrospective comparative study

 
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Annals of Gastroenterology
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Is complete mesocolic excision oncologically superior to conventional surgery for colon cancer? A retrospective comparative study (EN)

Dervenis, Christos
Theodorou, Demetrios
Xynos, Evaghelos
Agalianos, Christos
Gouvas, Nikolaos
Tsiaousis, John
Zografos, George
Theodoropoulos, George

Background During the last decade, many efforts have been made in order to improve the oncologic outcomes following colonic resection. Complete mesocolic excision (CME) has proved to provide high rates of disease-free and overall survival rates in patients undergoing resection for colonic malignancies. The aim of our study was to further investigate the role of CME in colonic surgery through comparison with a series of conventional resections.Methods All data regarding resections for colonic cancer since 2006 were obtained prospectively from two surgical departments. Retrieved data from 290 patients were analyzed and compared between those who underwent CME and those who had conventional surgery.Results The CME group presented a higher rate of postoperative morbidity and readmissions. Histopathological features were in favor of CME surgery compared with the conventional group, in terms of both resected bowel length (33 vs. 20 cm) and lymph node harvest (27 vs. 18). Although CME was associated with better disease-free and overall survival times, only tumor differentiation, adjuvant chemotherapy and age had a statistically significant affect on those outcome values (P<0.05).Conclusion CME improves histopathologic features, but without presenting oncologic superiority. Larger prospective studies following adequate surgical training are needed to prove the technique's advantages in oncologic outcomes.Keywords Colon cancer, complete mesocolic excision, oncological outcomesAnn Gastroenterol 2017; 30 (6): 688-696 (EN)

info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Society of Gastroenterology (EN)

2017-11-02


Hellenic Society of Gastroenterology (EN)

1792-7463
1108-7471
Annals of Gastroenterology; Volume 30, No 6 (2017); 688 (EN)



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