New insights into cholangiocarcinoma: multiple stems and related cell lineages of origin (EN)

Nevi, Lorenzo

Ridola, Lorenzo

Bragazzi, Maria Consiglia

Di Matteo, Sabina

Cardinale, Vincenzo

Costantini, Daniele

Safarikia, Samira

Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies that may develop at any level of the biliary tree. CCA is currently classified into intrahepatic (iCCA), perihilar (pCCA) and distal (dCCA) on the basis of its anatomical location. Notably, although these three CCA subtypes have common features, they also have important inter- and intra-tumor differences that can affect their pathogenesis and outcome. A unique feature of CCA is that it manifests in the hepatic parenchyma or large intrahepatic and extrahepatic bile ducts, furnished by two distinct stem cell niches: the canals of Hering and the peribiliary glands, respectively. The complexity of CCA pathogenesis highlights the need for a multidisciplinary, translational, and systemic approach to this malignancy. This review focuses on advances in the knowledge of CCA histomorphology, risk factors, molecular pathogenesis, and subsets of CCA.Keywords Cholangiocarcinoma, classifications, inflammation, cells of origin, stem cells, molecular profilingAnn Gastroenterol 2018; 31 (1): 42-55 (EN)

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info:eu-repo/semantics/publishedVersion

Ελληνική Γαστροεντερολογική Εταιρία

Annals of Gastroenterology

Invited Reviews

Αγγλική γλώσσα

2017-12-30

http://www.annalsgastro.gr/index.php/annalsgastro/article/view/3492

Hellenic Society of Gastroenterology (EN)

1792-7463

1108-7471

Annals of Gastroenterology; Volume 31, No 1 (2018); 42 (EN)