New insights into cholangiocarcinoma: multiple stems and related cell lineages of origin

This item is provided by the institution :

Repository :
Annals of Gastroenterology
see the original item page
in the repository's web site and access all digital files if the item*

2017 (EN)
New insights into cholangiocarcinoma: multiple stems and related cell lineages of origin (EN)

Nevi, Lorenzo
Ridola, Lorenzo
Bragazzi, Maria Consiglia
Di Matteo, Sabina
Cardinale, Vincenzo
Costantini, Daniele
Safarikia, Samira

Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies that may develop at any level of the biliary tree. CCA is currently classified into intrahepatic (iCCA), perihilar (pCCA) and distal (dCCA) on the basis of its anatomical location. Notably, although these three CCA subtypes have common features, they also have important inter- and intra-tumor differences that can affect their pathogenesis and outcome. A unique feature of CCA is that it manifests in the hepatic parenchyma or large intrahepatic and extrahepatic bile ducts, furnished by two distinct stem cell niches: the canals of Hering and the peribiliary glands, respectively. The complexity of CCA pathogenesis highlights the need for a multidisciplinary, translational, and systemic approach to this malignancy. This review focuses on advances in the knowledge of CCA histomorphology, risk factors, molecular pathogenesis, and subsets of CCA.Keywords Cholangiocarcinoma, classifications, inflammation, cells of origin, stem cells, molecular profilingAnn Gastroenterol 2018; 31 (1): 42-55 (EN)




Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 31, No 1 (2018); 42 (EN)

*Institutions are responsible for keeping their URLs functional (digital file, item page in repository site)