Familial and ethnic risk in inflammatory bowel disease (EN)

Gomes, Catarina

Torres, Joana

Costa Santos, Maria Pia

Familial aggregation in inflammatory bowel disease (IBD) has been established for several decades, reflecting shared genetic and environmental susceptibility. A positive family history remains the strongest recognizable risk factor for the development of IBD and is reported in around 8-12% of IBD patients. Crohn's disease shows a more frequent familial pattern than ulcerative colitis. The risk of developing IBD in first-degree relatives of an affected proband is increased 4- to 8-fold. The risk for twins and children born from couples who both have IBD is also substantially higher; a cumulative effect of the number of family members affected has been described, with the highest incidence being described for families with three or more affected members. Herein, we review the available evidence regarding familial IBD, and briefly discuss the variation of IBD across different races and ethnicities, hoping to provide a useful update and a practical guide that can serve clinicians as a guide for counseling.Keywords Inflammatory bowel disease, familial risk, ethnic risk, first-degree relatives, phenotype, counselingAnn Gastroenterol 2018; 31 (1): 14-23 (EN)

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

Ελληνική Γαστροεντερολογική Εταιρία

Annals of Gastroenterology

Invited Reviews

Αγγλική γλώσσα

2017-12-30

http://www.annalsgastro.gr/index.php/annalsgastro/article/view/3558

Hellenic Society of Gastroenterology (EN)

1792-7463

1108-7471

Annals of Gastroenterology; Volume 31, No 1 (2018); 14 (EN)