Prokinetic agents: current aspects with focus on cisapride

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Annals of Gastroenterology
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Report (EN)

2007 (EN)
Prokinetic agents: current aspects with focus on cisapride (EN)

Triantafillidis J.,
Markantonis-Kyroudis S., .
Georgiadis T., .

SUMMARY Prokinetic agents are substances which, through various mechanisms, stimulate gastrointestinal motor activity, e.g. cholinergic agonists, macrolide antibiotics (such as erythromycin), dopamine receptors antagonists (metoclopramide) and substituted benzamides (domperidone and cisapride). Cisapride is the only prokinetic agent which increases the motility of both the small and large bowel. Since 1993 when it was introduced to the pharmaceutical market, cisapride has been widely used with remarkable success in a variety of gastrointestinal diseases such as: gastrooesophageal reflux disease, gastric ulcer, chronic idiopathic constipation, irritable bowel syndrome, intestinal pseudoobstruction. Its major side-effects are gastrointestinal (abdominal pain, diarrhoea) and cardiovascular. Although it has always been considered an effective and rather safe medication, the large number of reports referring to serious and even fatal adverse effects on the cardiovascular system (QT interval extension, torsades de pointes, ventricular fibrillation) have prompted manufacturing company to withdraw the drug from the U.S. market as of July 12, 2000, pending further research. Key words: prokinetic agents, gastrointestinal hypomotility, pharmacodynamics, pharmacokinetics, drug interactions, side-effects (EN)




Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 13, No 4 (2000) (EN)

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