Beneficial effect of a polymeric feed, rich in TGF-b, on adult patients with active Crohn's disease: a pilot study

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2007 (EN)
Beneficial effect of a polymeric feed, rich in TGF-b, on adult patients with active Crohn's disease: a pilot study (EN)

A. Mastragelis, P. Cheracakis, F. Georgopoulos,
A. Gikas, Maria Sklavaina, Maria Mylonaki,, J.K. Triantafillidis, Asteria Stamataki,

So far, nutritional support with a polymeric diet rich in TGF-â has been studied only in children with Crohn’s disease and produced satisfactory results. There are no data concerning the effect of this kind of diet in adult patients with Crohn’s disease. The aim of this pilot study was to present our initial experience on the use of a polymeric diet rich in TGF-â in patients with mild or moderately active Crohn’s disease. Patients and Methods: Twenty nine patients with active Crohn’s disease received Modulen IBD as an exclusive diet for 4 weeks (50gx5/d). Patients continued to be on their regular conservative treatment (if so). Activity of the disease was assessed at the beginning of the therapeutic trial and after 4 weeks by the use of CDAI. Various anthropometric parameters and serum estimations, including ESR, CRP, platelets, albumin, vitamin B12 and folic acid were carried out at the beginning and after 4 weeks of application of the special diet. Results: Clinical improvement was noticed in 69% (20 out of 29 patients). No change of the situation or worsening was noticed in 9 patients (31%). The main alterations on anthropometric, hematological and biochemical parameters estimated before and after the application of the special diet are shown in the table. Parameter Before After P-value treatment treatment Body weight 61.7+/-13.8 63.2+/-13.6 0.003 Body Mass Index 21.2+/-4.5 21.7+/-4.0 0.002 Skin Fold 13.9+/-7.5 15.1+/-8.7 0 . 0 3 9 Thickness Mid Arm 26.7+/-4.5 28.1+/-4.8 0.004 Circumference Albumin 3.14+/-0.62 3.6+/-0.41 0.049 Fibrinogen 494.5+/-105.4 424.3+/-92.6 0.002 Folic acid 4.9+/-3.1 6.7+/-3.9 0.038 CRP 30.6+/-26.2 11.3+/-14.6 0.011 Immunoglobulin B 126.8+/-68.2 151.4+/-103.4 0.017 (Mean+/-1SD) Conclusion: Dietetic intervention with polymeric diet rich in TGF-â2 represents a quite satisfactory therapeutic modality in adult patients with mild to moderately active Crohn’s disease. However, these results must be confirmed in larger, randomized, placebo controlled clinical trials. Key words: Crohn’s disease, Inflammatory bowel disease, Inflammation, Transforming Growth Factor-â, Milk (EN)




Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 19, No 1 (2006) (EN)

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