Split- versus single-dose preparation tolerability in a multiethnic population: decreased side effects but greater social barriers

 
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2018 (EN)
Split- versus single-dose preparation tolerability in a multiethnic population: decreased side effects but greater social barriers (EN)

Goodman, Adam
Quiles, Kirsten
Perreault, Gabriel
Larion, Sebastian
Poles, Michael
Williams, Renee
Sen, Ahana

Background This study was performed to compare patient-reported tolerability and its barriers in single- vs. split-dose 4-L polyethylene glycol (PEG) bowel preparation for colonoscopy in a large multiethnic, safety-net patient population. Methods A cross-sectional, dual-center study using a multi-language survey was used to collect patient-reported demographic, medical, socioeconomic, and tolerability data from patients undergoing outpatient colonoscopy. Univariate and multivariate analyses were used to identify demographic and clinical factors significantly associated with patient-reported bowel preparation tolerability. Results A total of 1023 complete surveys were included, of which 342 (33.4%) completed singledose and 681 (66.6%) split-dose bowel preparation. Thirty-nine percent of the patients were Hispanic, 50% had Medicaid or no insurance, and 34% had limited English proficiency. Patients who underwent split-dose preparation were significantly more likely to report a tolerable preparation, with less severe symptoms, than were patients who underwent single-dose preparation. Multiple logistic regression revealed that male sex and instructions in the preferred language were associated with tolerability of the single-dose preparation, while male sex and concerns about medications were associated with tolerability of the split-dose preparation. Conclusions In a large multiethnic safety-net population, split-dose bowel preparation was significantly more tolerable and associated with less severe gastrointestinal symptoms than singledose preparation. The tolerability of split-dose bowel preparation was associated with social barriers, including concerns about interfering with other medications. Keywords Colonoscopy, bowel preparation, single-dose, split-dose, tolerability, safety-net Ann Gastroenterol 2018; 31 (3): 356-364 (EN)

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info:eu-repo/semantics/publishedVersion

Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Society of Gastroenterology (EN)

2018-05-02


Hellenic Society of Gastroenterology (EN)

1792-7463
1108-7471
Annals of Gastroenterology; Volume 31, No 3 (2018); 356 (EN)

Copyright (c) 2018 Annals of Gastroenterology (EN)



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