Non-Alcoholic steatohepatitis and primary hepatic carcinoma

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Editorial (EN)
Article (EN)

2007 (EN)
Non-Alcoholic steatohepatitis and primary hepatic carcinoma (EN)

D. Chirstodoulou, E.V. Tsianos,

SUMMARY Non-alcoholic fatty liver disease (NAFLD) has been recognized as the most frequent cause of chronic liver disease and comprises a spectrum of chronic liver diseases ranging from simple hepatic steatosis, to hepatic steatosis with non-specific hepatic inflammation, to non-alcoholic steatohepatitis (NASH) and finally cirrhosis. Few reports have been published so far about the incidence of primary hepatic carcinoma in patients with NAFLD and NASH. The importance of these findings remains to be defined, but one could speculate that hepatocellular carcinoma is part of the clinical spectrum of NAFLD and the metabolic derangement observed in patients with NAFLD may underlie the progression of liver disease to cirrhosis and hepatocellular carcinoma. Attempts should be made to interrupt the progression from simple fatty liver disease to steatohepatitis, fibrosis, cirrhosis and ultimately hepatocellular carcinoma. A behavioral approach, such as diet and exercise, to reduce the prevalence and the progression of obesity, diabetes and dyslipidemia, as well as the pharmacologic treatment of insulin resistance and the use of newer therapeutic agents of NASH, merit consideration in this clinical setting. (EN)




Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 17, No 3 (2004) (EN)

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