Acute idiopathic pancreatitis in patients with inflammatory bowel disease: A retrospective case-series description

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2007 (EN)
Acute idiopathic pancreatitis in patients with inflammatory bowel disease: A retrospective case-series description (EN)

E.G. Merikas, A. Gikas, Maria Mylonaki, F. Georgopoulos, J.K. Triantafillidis, P. Cheracakis,

SUMMARY Background/aims: To describe five patients who developed acute idiopathic pancreatitis either before (two patients) or after (three patients) the establishment of diagnosis of the underlying inflammatory bowel disease (IBD). Results: These patients represent an incidence for patient-years of 0.14% (3 cases with acute pancreatitis after the establishment of diagnosis of IBD per 2183 person-years, 95% CI 0.02-0.30%) and a frequency of 1.53 (5 patients with acute pancreatitis among 327 patients with IBD, 95% CI 0.20- 2.86%). Extensive work-up aiming to identify an etiological factor, known to be involved in the pathogenesis of acute pancreatitis was negative. Four of these patients had Crohn’s disease and one had ulcerative colitis. Three patients developed acute pancreatitis during a flare-up of the underlying IBD, while in two the appearance of acute pancreatitis preceded the clinical manifestations of IBD. The course of pancreatitis was favourable in the majority of cases. In one patient the administration of Infliximab resulted in prompt improvement of clinical and laboratory parameters. During the follow-up period, ranging from 14 months to 7 years, an exacerbation of pancreatitis was noted in one patient. Conclusion: This retrospective case-series suggests that acute idiopathic pancreatitis accompanies IBD, especially of Crohn’s disease, either before or following the establishment of diagnosis of IBD. Large epidemiological studies are needed in order to further clarify the relationship between acute idiopathic pancreatitis and IBD. Key words: Pancreatitis, idiopathic pancreatitis, inflammatory bowel disease, Crohn’s disease, ulcerative colitis (EN)




Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 17, No 3 (2004) (EN)

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