Hyperamylasemia as manifestation of gastrointestinal involvement in adult type Henoch-Schönlein purpura

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Annals of Gastroenterology
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Hyperamylasemia as manifestation of gastrointestinal involvement in adult type Henoch-Schönlein purpura (EN)

E. V. Tsianos, K.C. Siamopoulos, K. Katopodis, K.H. Katsanos,

SUMMARY Henoch-Schönlein purpura is a generalized vasculitis presenting with purpura, glomerulonephritis, cryoglobulinemia, arthralgias and acute abdominal pain. It occurs mainly in childhood and serum IgA is increased in half of the patients. A 54-year-old male patient was admitted to the Department of Nephrology because of lower extremities purpura, mild abdominal pain and acute renal failure (creatinine clearance at 60 ml/min). Physical examination showed both lower extremities purpura and mild epigastric tenderness. Abdominal imaging did not show anything remarkable. Further laboratory investigation showed serum urea 75 mg/dl, serum creatinine 1.9 mg/dl, amylase 600 UI/ ml (normal values up to 90 UI/ml) and albumin 3.2 gr/dl. Serum isoamylase analysis was compatible with that of pancreatic origin. Urine amylase was 138 UI/ml, while the examination of the urinary sediment showed microscopic hematuria and proteinuria. In the 24-hour urine collection albuminuria reached nephrotic syndrome levels (4.8gr/24h). There was no evidence of elevated IgA levels, of cryoglobulinemia or of circulating immune complexes. Skin and kidney biopsies confirmed Henoch-Schönlein purpura diagnosis. In conclusion, we report on an adult patient with hyperamylasemia during Henöch-Schonlein purpura initial diagnosis. Key words: Henoch-Schönlein purpura, pancreatitis, amylase, isoamylase, hyperamylasemia, abdominal pain (EN)


Αγγλική γλώσσα


Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 17, No 3 (2004) (EN)

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