A comparative study of combination octreotide plus methylprednisolone with octreotide and placebo on prevention of post-endoscopic retrograde cholangiopancreatography (ERCP)pancreatitis (EN)

Kalomenopoulou M.,

Katsiba D.,

Joseph Ch.,

Katsinelos P., .

Pilpilidis I.,

Vasiliadis Th.,

Christodoulou K., .

Xiarchos P.,

SUMMARY This study compares the effect of the combination of octreotide plus methylprednisolone with octreotide and placebo on biochemical and clinical parameters of endoscopic retrograde cholangiopancreatograpy (ERCP) induced pancreatitis. Two hundred and twenty two patients were randomised to receive either octreotide plus methylprednisolone, octreotide or placebo. There was no difference in the median serum amylase at 2 to 24 hours after ERCP in the three groups. Clinical pancreatitis, developed in 11 patients -one in the octretode plus methylprednisolone, four in the octretode and six in the placebo groups, although there was no statistically significant difference between the three groups. This study suggests a tendency that octreotide plus methylprednisolone may protect against ERCP- induced pancreatitis. Key words: Octreotide, Methylprednisolone, Hyperamylasemia, Pancreatitis, Endoscopic Retrograde Cholangiopancreatography. Abbreviations: Endoscopic Retrograde Cholangiopancreatography (ERCP), Endoscopic Sphincterotomy (ES) (EN)

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

Hellenic Society of Gastroenterology

Annals of Gastroenterology

English

2007-03-19

http://www.annalsgastro.gr/index.php/annalsgastro/article/view/40

Hellenic Society of Gastroenterology (EN)

1792-7463

1108-7471

Annals of Gastroenterology; Volume 13, No 4 (2000) (EN)