Extragastric manifestations of Helicobacter pylori infection: a critical reappraisal

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2007 (EN)
Extragastric manifestations of Helicobacter pylori infection: a critical reappraisal (EN)

Triantafillidis, Helen J.
Triantafillidis, J. K.

In recent years numerous studies have advocated a role for Helicobacter pylori in causing a variety of extragastric manifestations. These situations include Hematologic disorders such as iron-deficiency anemia and idiopathic thrombocytopenic purpura, vascular disorders such as ischemic heart disease, cerebral stroke, primary Raynaud phenomenon and primary headache, autoimmune diseases such as Sjogren’s syndrome, Henoch-Schonlein purpura, autoimmune thyroiditis, idiopathic arrythmias, Parkinson’s disease, nonarterial anterior optic ischemic neuropathy, cutaneous disorders, such as rosacea, pediatric diseases such as growth retardation and sudden infant death syndrome, renal failure, diabetes mellitus, respiratory disorders, and glaucoma. However, many of these reports suffer for being either case reports or case series without suitable controls. More importantly many of these reports include inadequate numbers of patients. Therefore, it could be supported that purported manifestations may represent a coincidental phenomenon. However, there are some situations that could really represent a true extragastric manifestation. These situations include sideropenic anemia (refractory iron deficiency) and immune thrombocytopenic purpura due to molecular mimicry. The search in this field must be continued using large number of patients and suitable controls. Confirmation of these results could probably modify our therapeutic guidelines for some disorders. Key words: Helicobacter pylori, Extragastric manifestations, Infections (EN)




Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 19, No 2 (2006) (EN)

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