δείτε την πρωτότυπη σελίδα τεκμηρίου στον ιστότοπο του αποθετηρίου του φορέα για περισσότερες πληροφορίες και για να δείτε όλα τα ψηφιακά αρχεία του τεκμηρίου*
Intestinal bacteria and permeability during experimental acute pancreatitis in rats
(EN)
Nehez, Laszlo
Andersson, Roland
Weström, Björn
Eckerwall, Gunilla
Soltesz, Vasile
Dib, Marwan
Norrman, Gustav
Background: An increase in intestinal permeability and subsequent
bacterial translocation has been demonstrated in
critical illness. Cellulose derivatives have in the past been
shown to reduce gut leakage following liver resection.
Aims: The aim of the present study was to evaluate changes
in microbial counts in experimental acute pancreatitis and
the effect of pre-treatment with cellulose derivatives and
N-acetyl cysteine.
Subjects: 92 male Sprague Dawley rats.
Methods: Acute pancreatitis was induced by intraductal taurodeoxycholic
acid infusion. Animals received oral pretreatment
and were randomized to either sham operation
or the pancreatitis groups, with or without pre-treatment
with cellulose derivatives, the antioxidant or their combinations.
Intestinal bacterial populations and permeability
were evaluated using bacterial counts and Ussing chamber,
respectively.
Results: The number of E. coli increased in the luminal content
and ileal and colonic mucosa, but levels were restored
to almost those seen in controls in all pre-treatment groups
except for N-acetyl cysteine. When intestinal permeability
was measured, none of the treatment groups showed sigNacetyl
cysteine, which significantly increased permeability.
Conclusion: Pre-treatment with cellulose derivatives was
more efficient against disturbances in intestinal permeability
and microbial populations than the antioxidant Nacetyl
cysteine.
Key words: acute pancreatitis, bacterial counts, dietary fibres,
intestinal permeability
Grants: Swedish Research Council (grant no 11236), Royal
Physiographic Society (Lund), Lars Hierta´s Minne, Crafoord
Foundation.
(EN)
Annals of Gastroenterology; Volume 19, No 3 (2006)
(EN)
*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.
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