Intestinal bacteria and permeability during experimental acute pancreatitis in rats

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2007 (EN)
Intestinal bacteria and permeability during experimental acute pancreatitis in rats (EN)

Nehez, Laszlo
Andersson, Roland
Weström, Björn
Eckerwall, Gunilla
Soltesz, Vasile
Dib, Marwan
Norrman, Gustav

Background: An increase in intestinal permeability and subsequent bacterial translocation has been demonstrated in critical illness. Cellulose derivatives have in the past been shown to reduce gut leakage following liver resection. Aims: The aim of the present study was to evaluate changes in microbial counts in experimental acute pancreatitis and the effect of pre-treatment with cellulose derivatives and N-acetyl cysteine. Subjects: 92 male Sprague Dawley rats. Methods: Acute pancreatitis was induced by intraductal taurodeoxycholic acid infusion. Animals received oral pretreatment and were randomized to either sham operation or the pancreatitis groups, with or without pre-treatment with cellulose derivatives, the antioxidant or their combinations. Intestinal bacterial populations and permeability were evaluated using bacterial counts and Ussing chamber, respectively. Results: The number of E. coli increased in the luminal content and ileal and colonic mucosa, but levels were restored to almost those seen in controls in all pre-treatment groups except for N-acetyl cysteine. When intestinal permeability was measured, none of the treatment groups showed sigNacetyl cysteine, which significantly increased permeability. Conclusion: Pre-treatment with cellulose derivatives was more efficient against disturbances in intestinal permeability and microbial populations than the antioxidant Nacetyl cysteine. Key words: acute pancreatitis, bacterial counts, dietary fibres, intestinal permeability Grants: Swedish Research Council (grant no 11236), Royal Physiographic Society (Lund), Lars Hierta´s Minne, Crafoord Foundation. (EN)


Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Society of Gastroenterology (EN)


Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 19, No 3 (2006) (EN)

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