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2007 (EN)
Selenium in the prevention of colorectal cancer (EN)

Tzouvala, Maria

Colorectal cancer remains a major cause of cancer related mortality and morbidity. Therefore, primary chemoprevention would be a desirable option. Recently, the trace element selenium (Se), has been evaluated in clinical trials, as a possible chemopreventive agent, in cancer. Several possible mechanisms for its potential anticarcinogenic effects have been proposed, however the exact mechanisms, by which selenium compounds exert these properties, is largely unknown. Results from epidemiological studies have been mixed and inconclusive. The true nature of the association between selenium deficiency and incidence of colorectal adenomas or cancer remains controversial. However, the limited clinical data suggest a potential benefit of Se supplementation. Yet, more conclusive evidence is needed before any dietary recommendation can be decided. Key words: Colorectal cancer, adenomas, prevention, selenium, selenoproteins, selenomethionine Colorectal cancer is one of the most common cancers (EN)




Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 19, No 3 (2006) (EN)

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