The impact of corticosteroids on hepatocytes ultrastructure experimental study in rats with electron microscopy

 
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2007 (EN)
The impact of corticosteroids on hepatocytes ultrastructure experimental study in rats with electron microscopy (EN)

Pilichos, Ch.
Kounavis, I.
Kapatsoris, D.
Fotiadis, C.
Preza, Athina

Background and Aim: Corticosterstoids are drugs widely used in common clinical practice.Their effect on liver morphology and function is not fully elucidated.The aim of this expenmental study is to investigate the impact of cortisol on fasted rat hepatocytes, by means of electron microscopy. Materials and Methods: Fifty male Wistar rats weighing 130-150gr were divided into two experimental groups: Group I (N=30): Hydrocortisol 8mg/100gr i.p. and Group II (N- 20): Normal saline i.p. Animals were sacrificed 30 min and 180 min after injection and liver specimens were taken. According to OsO4 -fixation protocol, ultra fine tissue sections were obtained and stained for electron microscopy. Results: The following findings were observed in >90% of cortisol treated animals and were significantly more frequent than in control group (P (EN)

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Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Society of Gastroenterology (EN)

2007-03-19


Hellenic Society of Gastroenterology (EN)

1792-7463
1108-7471
Annals of Gastroenterology; Volume 17, No 4 (2004) (EN)



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