The prophylactic effect of L-Arginine in an experimental model of acute ischemic colitis. A histopathological and biochemical (malondialdehyde levels) evaluation
Fotiadis C., .
Pilichos H., .
Papalois A., .
Poussios D., .
The aminoacid L-Arginine being the sole donor of nitric
oxide synthesis in cases of intestinal ischemia, seems to
play a protective role during experimental acute colon
ischemia and reperfusion. We studied the effect of pretreatment
with the aminoacid L-arginine in 144 Wistar rats who
were subjected to experimental acute ischemic colitis
(A.I.C.) and reperfusion of varying time periods (30, 60, 90
minutes). L-arginine was studied in comparison with Molcydomine
and Caseine, two substances used for intestinal
protection. Serum malondialdehyde (MDA) levels, a reliable
marker which indicate the degree of tissue damage after
ischemia-reperfusion, were lower in the L-arginine
group, while the same group presented the lower level of
histopathological damages. We conclude that pretreatment
with L-arginine in rats subjected to A.I.C. attenuates the
Key words: L-Arginine, Reperfusion injury, Intestinal
ischemia, Malondialdehyde, Experimental model.