The prophylactic effect of L-Arginine in an experimental model of acute ischemic colitis. A histopathological and biochemical (malondialdehyde levels) evaluation (EN)

Perrea P.,

Adamis S.,

Grigoriou Th.,

Sechas M.,

Fotiadis C., .

Pilichos H., .

Xekouki P.,

Perrea D.,

Pilichos H.,

Papalois A.,

Karayannakos P.,

Papalois A., .

Leventis J.,

Fotinou M.,

Karampela E.,

Preza A.,

Poussios D., .

Galanis G.,

SUMMARY The aminoacid L-Arginine being the sole donor of nitric oxide synthesis in cases of intestinal ischemia, seems to play a protective role during experimental acute colon ischemia and reperfusion. We studied the effect of pretreatment with the aminoacid L-arginine in 144 Wistar rats who were subjected to experimental acute ischemic colitis (A.I.C.) and reperfusion of varying time periods (30, 60, 90 minutes). L-arginine was studied in comparison with Molcydomine and Caseine, two substances used for intestinal protection. Serum malondialdehyde (MDA) levels, a reliable marker which indicate the degree of tissue damage after ischemia-reperfusion, were lower in the L-arginine group, while the same group presented the lower level of histopathological damages. We conclude that pretreatment with L-arginine in rats subjected to A.I.C. attenuates the histopathophysiological damages. Key words: L-Arginine, Reperfusion injury, Intestinal ischemia, Malondialdehyde, Experimental model. (EN)

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

Ελληνική Γαστροεντερολογική Εταιρία

Annals of Gastroenterology

Αγγλική γλώσσα

2007-03-19

http://www.annalsgastro.gr/index.php/annalsgastro/article/view/53

Hellenic Society of Gastroenterology (EN)

1792-7463

1108-7471

Annals of Gastroenterology; Volume 14, No 1 (2001) (EN)