Serum Pepsinogen I (PGI) and gastrin levels in children with gastritis
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Panayiotou, Joanna
Roma, Eleftheria
Kafritsa, Yota
Constantopoulos, A.
Barbatis, Calypso
Rokkas, T.
Loutsi, Helen
Background: Studies on the relationship of childhood gastritis
with serum PGI and gastrin are few. This prospective
study aimed to evaluate their use in the differential diagnosis
and assessment of the severity of childhood gastritis. Materials
and Methods: Serum PGI and gastrin G-17 (fast-postprandial)
were estimated by RIA in 101 symptomatic children,
aged 4-16 years (mean 102.7 y) who underwent endoscopy.
PGI and gastrin were reevaluated in 14 patients after H pylori
eradication. Results: A) 45 children had H pylori gastritis,
B) 35 non H. pylori gastritis and C) 21 had non H. pylori normal
gastric mucosa. A significant increase of PGI levels (70.9
 27.1 ng/ml) was found only in group A, compared to groups
B (46.412.9 ng/ml) and C (46.38 11.18 ng/ml p
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