Apoptosis and gastric carcinogenesis: Immunohistochemical analysis of Bax and Bcl-2 proteins

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2007 (EN)
Apoptosis and gastric carcinogenesis: Immunohistochemical analysis of Bax and Bcl-2 proteins (EN)

Voros, D.
Smyrniotis, V.
Kondi-Pafiti, Agatha
Chatzipantelis, P.
Konstantinou, P.

Aim: Our aim was to evaluate the role of Bax and Bcl-2 apoptosis- related proteins in the carcinogenesis of the stomach. Materials and Methods: 80 biopsy specimens and 50 surgical specimens of chronic gastritis, atrophic gastritis, intestinal metaplasia, gastric dysplasia and gastric cancer were studied. Routine hematoxyline and eosin sections were evaluated and classified according to the latest diagnostic criteria. Immunohistochemical methods were used for detection of Bax and Bcl-2. Results: The expression of Bax in precancerous lesions and in gastric cancer was distributed as follows: chronic gastritis 100% (80/80 cases), atrophic gastritis 60% (39/65 cases), intestinal metaplasia 55% (28/50 cases), dysplasia 25% (10/40 cases), intestinal type adenocarcinoma 40% (12/30 cases), and diffuse type adenocarcinoma 15% (3/20 cases). Bcl-2 expression was as follows: chronic gastritis 0%, atrophic gastritis 35% (23/65 cases), intestinal metaplasia 90% (45/50 cases), dysplasia 100% (40/40 cases), intestinal type adenocarcinoma 83.3% (25/30 cases), and diffuse type adenocarcinoma 70% (14/20 cases). Conclusions: Our findings demonstrate the high expression of Bcl-2 in precancerous lesions (intestinal metaplasia, dysplasia) and in gastric cancer; at the same time the suppression of Bax in these diseases is evident. This highlights the major role of Bcl-2 and the contradicting role of Bax in early carcinogenesis. Key Words: apoptosis, gastric carcinogenesis, Bax, Bcl-2 (EN)




Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 20, No 2 (2007) (EN)

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