Intestinal barrier dysfunction in obstructive jaundice: current concepts in pathophysiology and potential therapies

 
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Annals of Gastroenterology
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2007 (EL)
Intestinal barrier dysfunction in obstructive jaundice: current concepts in pathophysiology and potential therapies (EN)

Vagianos, C.E.
Assimakopoulos, S.F.
Nikolopoulou, Vassiliki N.

Patients with obstructive jaundice, especially when exposed to the additional stress of an invasive diagnostic or therapeutic procedure, are prone to septic complications and renal dysfunction contributing to high morbidity and mortality rates. The key-event in the pathophysiology of obstructive jaundice-associated complications is endotoxemia of gut origin because of intestinal barrier failure. Experimental and clinical studies have shown that obstructive jaundice results in increased intestinal permeability. The mechanisms implicated in this phenomenon remain unresolved, but over the last few years mainly experimental studies have shed light on our knowledge in the field. Factors such as altered intestinal tight junctions expression, oxidative stress and apoptosis may play a key role in gut permeability alterations in cases of biliary obstruction. This review summarises the current knowledge on the pathophysiological mechanisms and the potential therapeutic strategies. Clinicians facing this very common clinical problem should not neglect protecting the intestinal barrier function, which may improve their patients' outcome. Key words: obstructive jaundice, intestinal barrier, intestinal permeability, endotoxemia, bacterial translocation, tight junctions, occludin, claudin-4, apoptosis, oxidative stress (EN)

info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Society of Gastroenterology (EN)

2007-07-27


Hellenic Society of Gastroenterology (EN)

1792-7463
1108-7471
Annals of Gastroenterology; Volume 20, No 2 (2007) (EN)



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