Cytomegalovirus and Inflammatory Bowel Disease: pathogenicity, diagnosis and treatment

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2007 (EN)
Cytomegalovirus and Inflammatory Bowel Disease: pathogenicity, diagnosis and treatment (EN)

Mantzaris, G.
Zambeli, Evanthia
Christidou, Angeliki

Cytomegalovirus (CMV) infection is a common viral infection in humans. In immunocompromised patients such as transplant recipients and AIDS patients, CMV can cause severe disease, affecting multiple organs including the gastrointestinal tract. The role of CMV in patients with Inflammatory Bowel Disease (IBD) is controversial. CMV has been associated with onset of IBD, exacerbation of underlying IBD and refractoriness to medical treatment in some studies, but has been viewed as an "innocent bystander" in others. CMV infection must be distinguished from CMV disease but this may be difficult even with the newest diagnostic tests. Treatment with ganciclovir or foscarnet with or without discontinuation of immunosuppression, improves the clinical course of some IBD patients with CMV disease. Thorough clinical and laboratory evaluation is needed to identify those who will benefit from antiviral treatment until further studies reveal the exact role of CMV in the natural course of IBD. Key Words: Cytomegalovirus, Inflammatory Bowel Disease, ulcerative colitis, Crohn's disease, CMV colitis (EN)




Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 20, No 2 (2007) (EN)

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