The value of inflammation and coagulation markers for the assessment of the activity and clinical outcome of ulcerative colitis

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The value of inflammation and coagulation markers for the assessment of the activity and clinical outcome of ulcerative colitis (EN)

Evgenidis, N.
Patsiaoura, Kalliopi
Zezos, P.
Papaioannou, Georgia
Nikolaidis, N.
Vassiliadis, Th.
Mpoumponaris, A.
Giouleme, Olga

Aim: To investigate the value of various laboratory parameters in assessing the activity (diagnostic accuracy) and predicting the response to treatment (predictive value) of ulcerative colitis (UC). Methodology: Thirty-two patients with active and 12 patients with long standing inactive UC, based on clinical, endoscopic and histologic scores, were included. Laboratory routine variables (haemoglobin, platelets, albumin), inflammation (erythrocyte sedimentation rate [ESR], C-reactive protein [CRP], fibrinogen) and coagulation (D-Dimers, prothrombin fragments 1+2, thrombin-antithrombin complex, von Willebrand and VIII factors) indices were measured at baseline and after 12 weeks of treatment. The diagnostic accuracy (sensitivity, specificity, likelihood ratio) and the predictive value of all laboratory variables were calculated. Results: ESR, CRP, fibrinogen, haemoglobin, and von Willebrand factor, showed significant diagnostic accuracy, only when patients with long standing inactive UC, and not those in recent after treatment remission, were included in the calculations. Fibrinogen was the only variable that constantly differed significantly between patients with active and inactive disease (recent or long standing). None of the variables measured at baseline evaluation was effective in predicting the response to treatment. Conclusion:Inflammation variables, especially fibrinogen, are valuable markers of UC activity, while markers of coagulation and fibrinolysis activation are not. Laboratory variables are poor predictors of treatment response in active colitis. Endoscopy seems to be the most accurate and valuable tool for the assessment of colitis activity and monitoring the effect of treatment in UC patients. Key words: Coagulation, D-Dimers, factor VIII, fibrinolysis, inflammation, inflammatory bowel disease (IBD), prothrombin fragment 1 and 2 (F1+2), thrombin-antithrombin complex (TAT), ulcerative colitis (UC), von Willebrand factor. (EN)

Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Gastroenterologiki Company (EN)

2007-09-10


Annals of Gastroenterology (EN)

Annals of Gastroenterology; Volume 20, No 3 (2007) (EN)



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