Malignant cell interactions with cells of the hepatic sinusoids mediate primarily the development of colorectal cancer liver metastasis

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2008 (EN)
Malignant cell interactions with cells of the hepatic sinusoids mediate primarily the development of colorectal cancer liver metastasis (EN)

Canovas, D.
Bird, N.
Paschos, K.

Metastases are the main cause of death for patients with colorectal cancer and the liver is the primary host organ. However, macrometastases constitute the final step of a complicated and poorly-defined multistage process, named invasion- metastasis cascade. Before they metastasise, malignant cells undergo partial or complete transformation and acquire new properties. They present intensive growth, provoke neoangiogenesis, invade the surrounding extracellular matrix, detach from their primary site and intravasate. Some succeed in surviving in the systemic circulation, adhere to hepatic sinusoids and extravasate. Eventually, by evading the hepatic immune system, few cancer cells colonise the liver and form metastases. While a vast number of cells leave the primary tumour and intravasate, only a small minority reaches the liver blood network. Thus, the possibility of metastases formation is very low. The entrapment of colorectal cancer cells in the sinusoids and their interactions with the resident cells are considered very important initial steps in the liver invasion. Sinusoidal endothelial cells, pit cells, stellate cells and Kupffer cells all mediate the metastatic process in complex ways, through a variety of biological compounds and intercellular actions. Current research aims to elucidate the role of these cells in colorectal cancer liver metastasis. (EN)

info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Gastroenterologiki Company (EN)

2008-11-10


Hellenic Society of Gastroenterology (EN)

1792-7463
1108-7471
Annals of Gastroenterology; Volume 21, No 2 (2008); 98-108 (EN)



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