Effect of enteric coated sodium bicarbonate, enzymes and bile combination on the absorption of fat in chronic pancreatitis

 
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2007 (EN)
Effect of enteric coated sodium bicarbonate, enzymes and bile combination on the absorption of fat in chronic pancreatitis (EN)

Vukovic M., Jojic N., .

The effects of (A) H2-receptor antagonist (ranitidine) and enzyme preparation with bile constituents (Digestal forte), (B) Digestal forte and NaHCO3, (C) NaHCO3 alone, or (D) Digestal forte alone, on the increase of lipolysis, were studied in a double-blind, randomized, prospective, controlled cross-over study in 10 patients with chronic pancreatitis (CP) and steatorrhea. All preparations were enteric-coated tablets except ranitidine. The 14C triolein breath test was used to monitor the lipolytic effect of the regimens, the parameter for the efficacy assessment being cumulative recover (CR) of 14CO2 after 6 hours. Before the treatment patients underwent the same test procedure. The regimen B produced significantly higher increase in CR, as compared to other regimens (p0.05). The results showed that exogenous lipolytic action of Digestal forte remained unaffected by ranitidine (p>0.05). This study suggests that the adding of bicarbonate with Digestal forte may play an important role in the regulation of lypolysis in these patients. Key words: Chronic pancreatitis, enzyme substitution, bicarbonate, ranitidine (EN)

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Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Society of Gastroenterology (EN)

2007-03-18


Hellenic Society of Gastroenterology (EN)

1792-7463
1108-7471
Annals of Gastroenterology; Volume 13, No 2 (2000) (EN)



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