The influence of ranitidine bismuth citrate on rat gastric mucosal microcirculation and adherent mucus gel layer (EN)

Kotzampassi K., Paramythiotis D., Voudouris A., Milias K., Eleftheriadis E., .

Ranitidine Bismuth Citrate (RBC), recently developed to fight H. pylori, exhibits a triple action: anti-bacterial, antisecretive and mucosal-protective. Since less research has focused upon its mucosal protective action, we decided to study two parameters concerning that topic, i.e. the gastric mucosal blood flow and the adherent mucus gel thickness. Twenty rats were treated by gavage with either 25mg/kg RBC or equal volume (1ml) of drinking water; 60 min later, laparotomy was performed, the stomach opened along the greater curvature and gastric mucosal blood flow assessed by laser-Doppler flowmetry. After this measurement, five - 20mm long- fullthickness strips were sectioned from the stomach, mounted transversely on glass plates and viewed under a light microscopy using an eyepiece graticule (4 measurements/strip). Rats treated with RBC were found to exhibit a statistically significant increase in gastric mucosal blood flow (36.2916.64 vs 88.9912.23 relative units of flow, p=0.001) as well as in adherent mucus gel thickness (69.3021.7 vs 222.3947.71m, p=0.0001). It is thus concluded that the ability of RBC to increase gastric mucosal blood flow and adherent mucus gel thickness may contribute to the protective action of this compound. Key words: gastric mucosal blood flow, adherent mucus, ranitidine bismuth citrate, H. pylori (EN)

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

Ελληνική Γαστροεντερολογική Εταιρία

Annals of Gastroenterology

Αγγλική γλώσσα

2007-03-18

http://www.annalsgastro.gr/index.php/annalsgastro/article/view/7

Hellenic Society of Gastroenterology (EN)

1792-7463

1108-7471

Annals of Gastroenterology; Volume 13, No 2 (2000) (EN)