Causes and management of chronic hepatitis C in treatment experienced patients

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Causes and management of chronic hepatitis C in treatment experienced patients (EN)

Ilias, A.
Beltsis, A.

Chronic Hepatitis C is a major public health issue, affecting >2% of the worlds population. Combination treatment with pegylated interferon alfa and ribavirin is successful in achieving long-term viral suppression in about 50% of patients. The ever-growing population of relapsers and non-responders to PEG-IFN + ribavirin poses a difficult clinical problem. We investigate the causes of treatment failure, whether virus-related (HCV genotype, quasispecies diversity and viral load) or host-related (age, sex, race, fibrosis/cirrhosis, obesity and insulin resistance) and review the results of recently published trials on the treatment of relapsers and non-responders to PEG-IFN + ribavirin, focusing on the prognostic value of week 12 HCV-RNA measurements. (EN)

info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Gastroenterologiki Company (EN)

2009-10-05


Hellenic Society of Gastroenterology (EN)

1792-7463
1108-7471
Annals of Gastroenterology; Volume 22, No 4 (2009); 248 - 254 (EN)



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