Beneficial effect of a novel nonsteroidal anti-inflammatory agent with basic character and antioxidant properties on experimental colitis in rats (EN)

Papalois A.,

Triantafillidis J.,

Anagnostakis E.,

Andreadou I.,

Kourounakis P.,

Vidali M.,

Demonakou M.,

Govosdis V.,

SUMMARY Ulcerative colitis is a chronic disorder of unknown etiology. Conservative treatment remains empirical, even today. The aim of this study was to test the efficacy of a novel nonsteroidal anti-inflammatory agent {5-(2-hydroxy-ethylamino)- 1-cyclohexyl-2-pentanone} (compound A), with basic character and antioxidant properties on an experimental model of ulcerative colitis in rats. The effect of this compound was compared with that of methyl-prednisolone on the histological abnormalities and serum levels of Tumor Necrosis Factor –alpha (TNF-á© of experimental colitis produced by 2,4,6-trinitrobenzenesulfonic acid (TNB). A total number of 24 rats were used, randomly assigned to one of four groups of 6 rats each. Group 1: colitis without treatment (disease control), group 2: normal animals (control), group 3: induction of experimental colitis treated with methylprednisolone (5.3 x 10-3 mmol/kg i.v., every day for 7 days) and group 4: induction of experimental colitis plus administration of compound A (0.6 mmol/kg i.v., every day for 7 days). The administration of compound A resulted in a statistically significant reduction (p (EN)

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

Hellenic Society of Gastroenterology

Annals of Gastroenterology

English

2007-03-19

http://www.annalsgastro.gr/index.php/annalsgastro/article/view/93

Hellenic Society of Gastroenterology (EN)

1792-7463

1108-7471

Annals of Gastroenterology; Volume 14, No 4 (2001) (EN)