Simple and sure methodology for massive hepatectomy in the mouse


This item is provided by the institution :
Hellenic Society of Gastroenterology
Repository :
Annals of Gastroenterology
see item page
in the web site of the repository *

Semantic enrichment/homogenization by EKT
Simple and sure methodology for massive hepatectomy in the mouse (EN)

Nguyen, Justin H.
Ohashi, Norifumi
Gardner, Lindsay B.
Baine, Ann-Marie T.
Chen, Feng
Hori, Tomohide
Jermanus, Sura

Abstract Background. Reliable models for massive hepatectomy in the mouse are required for experimental liver research. Methods. We analyzed anatomical findings in 100 mice following massive hepatectomy induced by liver reduction >70%. The impact of various factors in the different models was also analyzed, including learning curves, operative time, survival curves and histopathological findings. Results. According to anatomical results, models with 75%, 80% and 90% hepatectomy produced massive hepatectomy. Learning curves and operative times were most optimal with the clip technique. Each hepatectomy performed using the clip technique produced a reasonable survival curve, and there were no differences in histopathological findings between the suture and clip techniques. Conclusion. Massive hepatectomy by the clip technique is simple and can provide reliable and relevant data. (EN)


Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Gastroenterologiki Company (EN)


Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 24, No 4 (2011); 307-318 (EN)

*Institutions are responsible for keeping their URLs functional (digital file, item page in repository site)