Study of DNA interactions with melphalan, busulphan, and analogues using an HPLC method

 
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2000 (EN)
Study of DNA interactions with melphalan, busulphan, and analogues using an HPLC method (EN)

Κωνσταντίνου-Κόκοτου, Βιολέτα (EL)
Κοκοτός, Γιώργος (EL)
Καρίκας, Γεώργιος-Αλβέρτος (EL)
Μαγκριώτη, Βικτώρια (EL)

Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Ιατρικών Εργαστηρίων (EL)

A simple reversed phase HPLC method suitable to study the interactions of alkylating agents with DNA is presented in this paper. DNA interaction is expressed as the % DNA peak size exclusion. The effects caused by the antitumor drugs melphalan, busulphan, and busulpan analogues on DNA were clearly observed through chromatographic data. The synthetic dimethanesulphonates of 2-tetradecyl-1,4-butanediol and 1,2-hexadecanediol were proved more potent than busulphan. Study of DNA interactions with melphalan, busulphan, and analogues using an HPLC method - ResearchGate. Available from: http://www.researchgate.net/publication/233043848_Study_of_DNA_interactions_with_melphalan_busulphan_and_analogues_using_an_HPLC_method [accessed May 9, 2015]. (EN)

journalArticle

μέθοδος HPLC (EN)
HPLC method (EN)
αλκυλιωτικοί παράγοντες (EN)
Alkylating agents (EN)
DNA (EN)
χρωματογραφικά δεδομένα (EN)
chromatographic data (EN)
δεοξυριβονουκλεϊκό οξύ (EN)

ΤΕΙ Αθήνας (EL)
Technological Educational Institute of Athens (EN)

Journal of Liquid Chromatography & Related Technologies (EN)

English

2000

DOI: 10.1081/JLC-100100457

N/A (EN)



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