Altered serum stress neuropeptide levels in critically ill individuals and associations with lymphocyte populations

This item is provided by the institution :
Technological Educational Institute of Athens
Repository :
Ypatia - Institutional Repository
see the original item page
in the repository's web site and access all digital files if the item*

2013 (EN)
Altered serum stress neuropeptide levels in critically ill individuals and associations with lymphocyte populations (EN)

Μπόζας, Ευάγγελος (EL)
Μπουζίκα, Μερόπη Δ. (EL)
Μίτλεττον, Νίκος (EL)
Παπαθανασόγλου, Ελισάβετ Δ. (EL)
Γιαννακοπούλου, Μαργαρίτα (EL)

Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας.Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Νοσηλευτικής (EL)
Καραμπίνης, Ανδρέας (EL)
Μπότη, Σοφία (EL)
Πατηράκη - Κουρμπάνη, Ελισάβετ Ι. (EL)

Objective Potential physiological correlates of stress and the role of stress neuropeptides, other than those of the hypothalamic-pituitary–adrenal axis, in critical illness have not been addressed. We investigated: (a) serum levels of stress neuropeptides (ACTH, substance P (SP), neuropeptide Y (NPY), cortisol, prolactin) in critically ill individuals compared to matched controls, (b) associations with lymphocyte counts, (c) associations among stress neuropeptide levels, and (d) associations with perceived intensity of stress, critical illness severity and survival. Methods Correlational design with repeated measures. Thirty-six critically ill patients were followed up for 14 days compared to 36 healthy matched controls. Stress was assessed by the ICUESS scale. Correlations, cross-sectional comparisons and multiple regression models were pursued. Results For the first time, we report lower SP (Difference of means (DM) = 2928–3286 ng/ml, p < 0.001) and NPY (DM = 0.77–0.83 ng/ml, p < 0.0001) levels in critically ill individuals compared to controls. Cortisol levels were higher (DM = 140–173 ng/ml, p < 0.0001) and lymphocyte population counts (p < 0.002) were lower in patients throughout the study. NPY levels associated with lymphocyte (r = 0.411–0.664, p < 0.04), T-lymphocyte (r = 0.403–0.781, p < 0.05), T-helper (r = 0.492–0.690, p < 0.03) and T-cytotoxic cell populations (r = 0.39–0.740, p < 0.03). On day 1, cortisol levels exhibited associations with lymphocyte (r = −0.452, p = 0.01), T-cell (r = −0.446, p = 0.02), T-helper (r = −0.428, p = 0.026) and T-cytotoxic cells (r = −0.426, p = 0.027). ACTH levels associated with NK cell counts (r = 0.326–0.441, p < 0.05). Associations among stress neuropeptides levels were observed throughout (p < 0.05). ACTH levels associated with disease severity (r = 0.340–0.387, p < 0.005). A trend for an association between ACTH levels and intensity of stress was noted (r = 0.340, p = 0.057). Conclusion The significantly lowered NPY and SP levels and the associations with cortisol, ACTH and lymphocytes suggest that the role of these peptides in critical illness merit further investigation. Future studies need to address associations between these neuropeptides and functional immune cell responses and inflammatory markers in critical illness. (DE)


Neuropeptide Y (EN)
Νευροπεπτίδια (EN)
Λεμφοκύτταρα (EN)
Lymphocytes (EN)
Substance P (EN)
Neuropeptides (EN)
Stress (Physiology) (EN)
Το νευροπεπτίδιο Υ (EN)
Η ουσία Ρ (EN)
Στρες (Φυσιολογία) (EN)

ΤΕΙ Αθήνας (EL)
Technological Educational Institute of Athens (EN)

Neuropeptides (EN)




N/A (EN)

*Institutions are responsible for keeping their URLs functional (digital file, item page in repository site)