Dosimetric characteristics of a new polymer gel and their dependence on post-preparation and post-irradiation time

 
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2013 (EN)
Dosimetric characteristics of a new polymer gel and their dependence on post-preparation and post-irradiation time (EN)

Παπαδάκης, Αντώνιος Ε. (EL)
Μαρής, Θωμάς Γ. (EL)
Παππάς, Ευάγγελος (EL)
Δαμηλάκης, Iωάννης (EL)
Παπουτσάκη, Μαριάνθη - Βασιλική (EL)

Τ.Ε.Ι. Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Ραδιολογίας και Ακτινολογίας. (EL)

The aim of this study is to dosimetrically characterize a new MRI based polymer gel system and to evaluate its usefulness in clinical practice just in terms of beam profile measurements. Normoxic N-vinylpyrrolidone based polymer gel (VIPET) phantoms were produced and used in order to perform three main sets of experiments: a) dose–response evaluation and reproducibility experiments, b) experiments for the evaluation of sensitivity of dose characteristics on ‘gel manufacture – irradiation’ time interval and c) experiments for the evaluation of sensitivity of dose characteristics on ‘irradiation – MRscanning’ time interval. It has been shown that this gel system can be used in a wide dose-range of 0–60 Gy. It exhibits a linear dose–response in the dose-range of 2–35 Gy. Following the proposed manufacturing method the dose–response characteristics are reproducible. Moreover, it seems that the optimum ‘gel manufacturing – irradiation’ time interval is 1 day. However, a ‘gel manufacturing – irradiation’ time interval up to ∼1 week can be safely used. The optimum ‘irradiation – MRscanning’ time interval in terms of dose–response sensitivity and dose resolution can be reliably ranged from 1 day to 3 weeks. Finally, X-ray beam profile gel-measurements were performed and found to be in satisfying agreement with corresponding small sensitive volume ion chamber measurements. VIPET gel dosimeters preserved the spatial integrity of the dose distribution during a time period of 50 days post-irradiation. The studied gel system can be safely used in clinical practice within the practical limitations found and described in this work. (EN)

journalArticle

Magnetic resonance imaging (EN)
Normoxic polymer gel dosimetry (EN)
Προφίλ δέσμης (EN)
Beam profile (EN)
Radiotherapy (EN)
Μαγνητική τομογραφία (EN)
Ακτινοθεραπεία (EN)

ΤΕΙ Αθήνας (EL)
Technological Educational Institute of Athens (EN)

Physica Medica (EN)

English

2013-09

doi:10.1016/j.ejmp.2013.01.003

N/A (EN)



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