Formation, evaluation and optimization of orally disintegrating tablet of Cinnarizine

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Formation, evaluation and optimization of orally disintegrating tablet of Cinnarizine

Prajapati, Bhupendra G.
Patel, Satish N.

e-Journal of Science & Technology
Objective of this study was to formulate directly compressible orally disintegrating tablets of Cinnarizine with sufficient mechanical integrity, content uniformity, and acceptable palatability to assist patients of any age group for easy administration. Effect of varying concentrations of different superdisintegrants such as crospovidone, croscarmellose sodium, and sodium starch glycolate on disintegration time was studied. Tablets were evaluated for weight variation, thickness, hardness, friability, taste, drug content, in vitro disintegrating time and in vitro drug release. Other parameters such as wetting time, water absorption ratio (‘R’), and drug-excipient compatibility were also evaluated. The disintegration time of the optimized CP5 batch was 25 sec. Good correlation was observed between disintegration time and water absorption ratio (R) for each of three superdisintegrants at concentrations studied. Considering the ‘R’ values and disintegration time, crospovidone was significantly superior compared to other two superdisintegrants tested. Release of drug was faster from formulations containing 6% crospovidone (CP5) compared to the marketed convetional Cinnarizine tablet. Differential scanning calorimetric studies did not indicate any excipient incompatibility, either during mixing or after compression. Finally concluded that directly compressible orally disintegrating tablets of cinnarizine with lower friability, acceptable taste, and shorter disintegration times were obtained using crospovidone at optimized concentrations.
e-Περιοδικό Επιστήμης & Τεχνολογίας


Χρόνος διαβροχής
Orally disintegrating tablet
Wetting time
Στοματικό διαλυόμενο δισκίο
Αναλογία απορρόφησης νερού
Water absorption ratio

e-Journal of Science & Technology
e-Περιοδικό Επιστήμης & Τεχνολογίας

Αγγλική γλώσσα


Prajapati, B.G. and Patel, S.N. (2010). Formation, evaluation and optimization of orally disintegrating tablet of Cinnarizine. "e-Journal of Science & Technology". [Online] 5(5): 9-21. Available from:

Σιανούδης, Ιωάννης
Νερατζής, Ηλίας

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