Reactions of N-hydroxysuccinimide esters of N-alkoxycarbonyl-α-amino acids with active methylene compounds. Synthesis of 3-substituted tetramic acids
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Markopoulos, J
(EN)
Detsi, A
(EN)
Igglessi-Markopoulou, O
(EN)
The N-hydroxysuccinimide esters of N-alkoxycarbonyl-alpha-amino acids react with active methylene compounds (cyanoacetic esters,malonic and acyl acetic esters), under basic conditions, to produce 3-substituted N-alkoxycarbonyl tetramic acids; in the case of the N-hydroxysuccinimide esters derived from L-aminoacids, the corresponding optically active tetramic acids are obtained.
(EN)
