Reactions of N-hydroxysuccinimide esters of N-alkoxycarbonyl-α-amino acids with active methylene compounds. Synthesis of 3-substituted tetramic acids

 
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1996 (EN)
Reactions of N-hydroxysuccinimide esters of N-alkoxycarbonyl-α-amino acids with active methylene compounds. Synthesis of 3-substituted tetramic acids (EN)

Markopoulos, J (EN)
Detsi, A (EN)
Igglessi-Markopoulou, O (EN)

N/A (EN)

The N-hydroxysuccinimide esters of N-alkoxycarbonyl-alpha-amino acids react with active methylene compounds (cyanoacetic esters,malonic and acyl acetic esters), under basic conditions, to produce 3-substituted N-alkoxycarbonyl tetramic acids; in the case of the N-hydroxysuccinimide esters derived from L-aminoacids, the corresponding optically active tetramic acids are obtained. (EN)

journalArticle

Amino Acid (EN)
3-ACYLTETRAMIC ACIDS (EN)
FULIGORUBIN-A (EN)
ACYLAMINOACETYL DERIVATIVES (EN)
CYCLIZATION (EN)

Εθνικό Μετσόβιο Πολυτεχνείο (EL)
National Technical University of Athens (EN)

Chemical Communications (EN)

1996


ROYAL SOC CHEMISTRY (EN)



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