ΔΙΕΙΣΔΥΣΗ ΤΩΝ ΠΡΩΤΗΣ-ΔΕΥΤΕΡΗΣ ΚΑΙ ΤΡΙΤΗΣ ΓΕΝΙΑΣ ΚΕΦΑΛΟΣΠΟΡΙΝΩΝ ΣΤΟ ΜΗΤΡΙΚΟ ΓΑΛΑ
PENETRATION OF FIRST, SECOND AND THIRD GENERATION CEPHALOSPORINS INTO THE BREAST MILK
Κωνσταντάτος, Παναγιώτης
THE CONCENTRATIONS OF EIGHT FIRST, SECOND AND THIRD GENERATION CEPHALOSPORINS WERE STUDIED IN VOLUNTARILLY PARTICIPATING LACTATING MOTHERS USING STANDARD ASSAY METHODS. EACH MOTHER RECEIVED ONE SINGLE DOSE OF 1 GR OF EITHER AN ORALLY OR INTRAVENOUSLY ADMINISTRATED ANTIBIOTIC. CEPHALEXIN AND CEFDROXIC, OF THE FIRST GENERATION CEPHALOSPORINS WERE GIVEN ORALLY AND PECK MILD CONCENTRATIONS AVERAGED 0,50 +- 0,23 MG/ML AT 4 HOURS AND 1,64 +- 0,73 MG/ML AT 6 HOURS RESPECTIVELY, CEPHATOTHIN, CEPHASPIRIN AND CEPHAZOLINE WERE GIVEN AS AN IV BOLUS INJECTION AND MILK CONCENTRATIONS AT 8 HOURS AVERAGED 0,47 +- 0,14 MG/ML, 0,43+-0,16 MG/ML AND AT 3 HOURS /, E +- 0,62 MG/ML RESPECTIVELY. (SHORTENED)
