Calreticulin Synthetic Peptide Analogs - Antipeptide Antibodies in Autoimmune Rheumatic Diseases

 
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1993 (EN)
Calreticulin Synthetic Peptide Analogs - Antipeptide Antibodies in Autoimmune Rheumatic Diseases (EN)

Routsias, J. G. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Routsias, J. G. (EN)

Autoantibodies in sera from patients with systemic lupus erythematosus (SLE) and onchocerciasis recognize calreticulin (CaR), a calcium-binding protein, as antigen. In this study we present the immunological properties of two synthetic peptides prepared to correspond to the 1-24 and 7-24 amino acid sequence of CaR. In contrast to information previously reported for the recombinant protein, the CaR-peptide analogues appeared immunoreactive to anti-Ro/SSA autoimmune sera. Human sera from patients with SLE, Sjogren's syndrome (SS), rheumatoid arthritis (RA), as well as mixed connective tissue disease (MCTD), demonstrated a positive autoimmune response (binding of antibodies), to the CaR-peptide analogues. These findings suggest that anti-calreticulin autoantibodies are not restricted to any disease specificity. (EN)

calreticulin (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

Clin Exp Immunol (EN)

1993

<Go to ISI>://A1993KP26700016

Blackwell (EN)



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