Interaction of [(Dien)Ptbr]Br with 6-Oxopurine Nucleosides
(EN)
Theodorou, V.
(EN)
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
(EL)
Theodorou, V.
(EN)
Complexes of the general formulae [(dien)Pt(nucl)]Br2, with nucl=guanosine (guo), inosine (ino), xanthosine (xao) and 9-methyl guanine (9-MeG) were first isolated from the reactions of [(dien)PtBr]Br with the nucleosides. Further reactions between the [(dien)Pt(nucl)]Br2, [(dien)PtBr]Br and K2PtX4 (X=Cl, Br) complexes produced new ones of formulae [(dien)Pt(nucl-H+)]Br, [{(dien)Pt}2(nucl-H+)](ClO4)3, [(dien)Pt(nucl-H+)PtX3] and [(dien)Pt(nucl)](PtX4) (X=Cl, Br). All complexes were characterized by elemental analysis, conductivity measurements, IR and H-1 NMR spectra. All the nucleosides are firstly coordinated through their N7 atoms. This is followed by an attack of a second Pt(II) atom at N1, after deprotonation of this site in the dinuclear complexes.
(EN)
