Metal ion-drug interactions. Preparation and properties of manganese (II), cobalt (II) and nickel (II) complexes of diclofenac with potentially interesting anti-inflammatory activity: Behavior in the oxidation of 3,5-di-tert-butyl-o-catechol
Metal ion-drug interactions. Preparation and properties of manganese (II), cobalt (II) and nickel (II) complexes of diclofenac with potentially interesting anti-inflammatory activity: Behavior in the oxidation of 3,5-di-tert-butyl-o-catechol
(EN)
Kovala-Demertzi, D.
(EN)
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
(EL)
Kovala-Demertzi, D.
(EN)
Some new complexes of diclofenac with potentially interesting biological activity are described. The complexes of diclofenac [MnL2(H2O)], [CoL2(H2O)(2)](.)0.5H(2)O, [CoL2(H2O)], [NiL2(H2O)(2)](.)2H(2)O, and [NiL2], were prepared by the reaction of the sodium salt, of a potent anti-inflammatory drug with MnCl2, CoCl2 and NiCl2. 6H(2)O. Optical, EPR, infrared and electrochemical properties of these new complexes are reported. Both five and six-coordinated species were isolated in the solid state for Co(II). Both four and six-coordinated species were isolated in the solid state for Ni(II), while in DMF or MeOH solution predominant formation of six-coordinated species is observed for Co(II) and Ni(II) complexes. The ability of the complexes to catalyze the oxidation of 3,5-di-tert-butyl-o-catechol to 3,5-di-tert-butyl-o-quinone was studied by following the appearance of quinone spectrophotometrically. Correlation of the catalytic activity of these complexes to the reduction potential is reported. (C) 1998 Elsevier Science Inc. All rights reserved.
(EN)
