Non-enzymatic platelet-activating factor formation by acetylated proteins

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2004 (EN)
Non-enzymatic platelet-activating factor formation by acetylated proteins (EN)

Thanou, P. G. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Thanou, P. G. (EN)

Substantial amounts of platelet-activating factor (PAF 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine), the potent phospholipid mediator of allergic and inflammatory reactions, are formed upon incubation of acetylated low-density lipoprotein, acetylated bovine serum albumin (BSA) and acetylated apolipoprotein A-I with 1-0-hexadecyl-sn-glycero-3-phosphocholine (lyso-PAF). Acetylated BSA produced 0.3 nmol PAF/mg of protein after a 6 h incubation period with 40 muM lyso-PAF. The transfer of acetate bound to acetylated proteins to lyso-PAF was non-enzymatic. Chemical PAY formation by acetylated proteins, involved in lipid metabolism and transport, could lead to complication of inflammatory and allergic events. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. (EN)

platelet-activating factor (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

FEBS Lett (EN)



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