Organotin flufenamates: Synthesis, characterization and antiproliferative activity of organotin flufenamates
(EN)
Kovala-Demertzi, D.
(EN)
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
(EL)
Kovala-Demertzi, D.
(EN)
The organotin flufenamates [Me(2)(flu)SnOSn(flu)Me(2)](2) (1), [Bu(2)(flu)SnOSn(flu)Bu(2)](2) (2) and [Bu(2)Sn(flu)(2)] (3) have been prepared and structurally characterized by means of vibrational and NMR ((1)H, (13)C and (119)Sn) spectroscopy. The crystal structure of [Me(2)(flu)SnOSn(flu)Me(2)](2) (1) has been determined by X-ray crystallography. Three distannoxane rings are present to the dimeric tetraorganodistannoxane of planar ladder arrangement. The structure is centro-symmetric and features a central rhombus Sn(2)O(2) unit with two additional tin atoms linked at the O atoms. Six-coordinated tin centers are present in the dimer distannoxane. This structure is self-assembled via pi -> pi and C-H -> pi stacking interactions. Flufenamic acid and flufenamates were evaluated for antiproliferative activity in vitro. Among the compounds tested [Bu(2)(flu)SnOSn(flu)Bu(2)](2) (2) and [Bu(2)Sn(flu)(2)] (3) exhibited high cytotoxic activity against the cancer cell line A549 (non-small cell lung carcinoma). (c) 2005 Elsevier B.V. All rights reserved.
(EN)
