Organotin-drug interactions. Organotin adducts of lornoxicam, synthesis and characterisation of the first complexes of lornoxicam

 
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2003 (EN)
Organotin-drug interactions. Organotin adducts of lornoxicam, synthesis and characterisation of the first complexes of lornoxicam (EN)

Galani, A. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Galani, A. (EN)

The synthesis and spectral characterisation of novel organotin complexes [SnMe2(lorn)] (1) and [SnBu2(lorn)] (2) of the potent and widely used anti-inflammatory drug lornoxicam, H(2)lorn, are reported. Crystal structure determinations of complexes1 and 2 showed that the ligand is doubly deprotonated at the oxygen and amide nitrogen atoms and is coordinated to the SnR2 fragment via four- and six-membered chelate rings. The monomers of 1 are linked through intermolecular hydrogen bonds of C-H--O type and through C-H-pi intermolecular interactions. There are two similar molecules in the asymmetric unit of 2. The dimers of 2 are arranged in polymers with a stacking of alternate parallel chains and are linked through intermolecular hydrogen bonds of C-H--O type, and through C-H-n intermolecular interactions. An extended network of Sn-O-Sn, C-H--O and C-H--pi contacts lead to aggregation and a supramolecular assembly. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003). (EN)

antitumour agents (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

European Journal of Inorganic Chemistry (EN)

English

2003

<Go to ISI>://000182964000014



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