Organotin-drug interactions. Organotin adducts of lornoxicam, synthesis and characterisation of the first complexes of lornoxicam
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Galani, A.
(EN)
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
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Galani, A.
(EN)
The synthesis and spectral characterisation of novel organotin complexes [SnMe2(lorn)] (1) and [SnBu2(lorn)] (2) of the potent and widely used anti-inflammatory drug lornoxicam, H(2)lorn, are reported. Crystal structure determinations of complexes1 and 2 showed that the ligand is doubly deprotonated at the oxygen and amide nitrogen atoms and is coordinated to the SnR2 fragment via four- and six-membered chelate rings. The monomers of 1 are linked through intermolecular hydrogen bonds of C-H--O type and through C-H-pi intermolecular interactions. There are two similar molecules in the asymmetric unit of 2. The dimers of 2 are arranged in polymers with a stacking of alternate parallel chains and are linked through intermolecular hydrogen bonds of C-H--O type, and through C-H-n intermolecular interactions. An extended network of Sn-O-Sn, C-H--O and C-H--pi contacts lead to aggregation and a supramolecular assembly. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).
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