Palladium(II) complexes of 2-acetylpyridine N(4)-propyl, N(4)-dipropyl- and 3-hexamethyleneiminylthiosemicarbazones with potentially interesting biological activity. Synthesis, spectral properties, antifungal and in vitro antitumor activity
Palladium(II) complexes of 2-acetylpyridine N(4)-propyl, N(4)-dipropyl- and 3-hexamethyleneiminylthiosemicarbazones with potentially interesting biological activity. Synthesis, spectral properties, antifungal and in vitro antitumor activity
(EN)
KovalaDemertzi, D.
(EN)
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
(EL)
KovalaDemertzi, D.
(EN)
Some new palladium(II) complexes of 2-acetylpyridine N(4)-propyl-and N(4)dipropyl- and 3-hexamethyleneiminylthiosemicarbazones with potentially interesting biological activity were described. The thiosemicarbazones and their palladium(II) complexes have been characterized by spectroscopic, and electrochemical techniques. The protonation constants of HAc4P K-a1 and K-a2, were determined by spectrophotometry and the pK(1a) and pK(a2) values are equal to 12.23 +/- 0.02 and 4.11 +/- 0.02. The antifungal properties and the effect selected compounds on DNA synthesis of P388 and L1210 cell cultures is reported. (C) 1997 Elsevier Science Ltd.
(EN)
