Phospholipase A(2) subclasses in acute respiratory distress syndrome

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Phospholipase A(2) subclasses in acute respiratory distress syndrome (EN)

Kitsiouli, E. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Kitsiouli, E. (EN)

phospholipases A(2), (PLA(2)) catalyse the cleavage of fatty acids esterified at the sn-2 position of glycerophospholipids. In acute lung injury-acute respiratory distress syndrome (ALI-ARDS) several distinct isoenzymes appear in lung cells and fluid Some are capable to trigger molecular events leading to enhanced inflammation and lung damage and others have a role in lung surfactant recycling preserving lung function Secreted forms (groups sPLA(2)-IIA, -V, -X) can directly hydrolyze surfactant phospholipids Cytosolic PLA(2) (cPLA(2)-IVA) requiring Ca(2+) has a preference for arachidonate, the precursor of etcosanoids which participate in the inflammatory response in the lung. Ca(2+) independent intracellular PLA(2)s (iPLA(2)) take part in surfactant phospholipids turnover within alveolar cells Acidic Ca(2+) -independent PLA(2) (aiPLA(2)). of lysosomal origin. has additionally antioxidant properties, (peroxiredoxin VI activity). and participates in the formation of dipalmitoyl-phosphatidylcholine in lung surfactant. PAF-AH degrades PAF. a potent mediator of inflammation, and oxidatively fragmented phospholipids but also leads to toxic metabolites. Therefore, the regulation of PLA(2) isoforms could be a valuable approach for ARDS treatment. (C) 2009 Elsevier B.V All rights reserved. (EN)

ali (EN)

Biochimica Et Biophysica Acta-Molecular Basis of Disease (EN)



Elsevier (EN)

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