Photo-activated metallotherapeutics; Copper(I) or silver(I) mixed ligand complexes with 2-mercaptopyrimidine and triphenylphosphine

 
This item is provided by the institution :
University of Ioannina
Repository :
Repository of UOI Olympias
see the original item page
in the repository's web site and access all digital files if the item*
share



2013 (EN)
Photo-activated metallotherapeutics; Copper(I) or silver(I) mixed ligand complexes with 2-mercaptopyrimidine and triphenylphosphine (EN)

Velalopoulou, A. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Velalopoulou, A. (EN)

Five photosensitive, copper(I) or silver(I) mixed ligand complexes with 2-mercaptopyrimidine (pmtH) and triphenylphosphine (tpp) of formulae [CuCl(tpp)2(pmtH)] (1), {[Cu(tpp)(pmt)]2 0.5(MeOH)} (2), [CuSH(tpp)2(pmtH)] (3), [Cu(tpp)2(pmt)] (4), and [AgCl(tpp)2(pmtH)] (5) were tested for their in vitro cytotoxic activity against leiomyosarcoma cells (LMS), human breast adenocarcinoma cells (MCF-7) normal fibroblasts (MRC-5), before and after UV-C irradiation, using MTT assay. The incubation time (curve) for complexes with cells and irradiation time, were also studied. The type of LMS cell death caused by the complexes was also evaluated by flow cytometry assay. The results show that at concentration of 1.2-9.5 ΞΌM of 1-5, 35-98 % of LMS cells undergo programed cell death (apoptosis). The light sensitivity of the complexes is discussed in relation with their biologic activity. All complexes presented significant cytotoxic activity, which has been enhanced by photoactivation. (EN)

Bioinorganic chemistry (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

Medicinal Chemistry Research (EN)

English

2013


Springer-Verlag (EN)



*Institutions are responsible for keeping their URLs functional (digital file, item page in repository site)