Platinum(II) and palladium(II) complexes with 2-acetylpyridine thiosemicarbazone: cytogenetic and antineoplastic effects

 
This item is provided by the institution :
University of Ioannina
Repository :
Repository of UOI Olympias
see the original item page
in the repository's web site and access all digital files if the item*
share



2001 (EN)
Platinum(II) and palladium(II) complexes with 2-acetylpyridine thiosemicarbazone: cytogenetic and antineoplastic effects (EN)

Iakovidou, Z. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Iakovidou, Z. (EN)

The effect of three novel complexes of Pt(II) and three complexes of Pd(II) with 2-acetylpyridine thiosemicarbazone (HAcTsc) on sister chromatid exchange (SCE) rates and human lymphocyte proliferation kinetics on a molar basis was studied. Also, the effect of Pt(II) and Pd(II) complexes against leukemia P388 was investigated. Among these compounds, the most effective in inducing antitumor and cytogenetic effects were the complexes [Pt(AcTsc)(2)].H2O and [Pd(AcTsc)(2)] while the rest, i.e. (HAcTsc), [Pt(AcTsc)CI], [Pt(HAcTsc)(2)]Cl-2. 2H(2)O, [Pd(AcTsc)Cl] and [Pd(HAcTsc)(2)]Cl-2, displayed marginal cytogenetic and antitumor effects. [(C) 2001 Lippincott Williams & Wilkins.]. (EN)

2-acetylpyridine thiosemicarbazone (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

Anticancer Drugs (EN)

English

2001

<Go to ISI>://000166756100009



*Institutions are responsible for keeping their URLs functional (digital file, item page in repository site)